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Prospective Cohort Study of BRCA1 and BRCA2 Mutation Carriers and Non-Carriers with Compelling Family History (UPENN PROSE study)




Prospective Cohort Study of BRCA1 and BRCA2 Mutation Carriers and Non-Carriers with Compelling Family History (UPENN PROSE study) (IRB 006-037)

Study Description:

The primary objective of this study is to estimate the incidence of breast, ovarian and other cancers in a prospective cohort of female BRCA1 and BRCA2 mutation carriers.

Inclusion Criteria:

» Study subjects will be living women who are above the age of 20 and who have participated in a genetic testing program. These women will have consented in writing to have predictive testing done on DNA samples extracted from their blood. They will have been found to be carriers of deleterious mutations in the BRCA1 or BRCA2 gene. They may have a cancer diagnosis or may not be affected by cancer. They will have completed genetic counseling. In addition, women who have been diagnosed with a primary breast cancer and other type of primary cancer who have or have not had genetic testing will be eligible. These women will be given genetic counseling through the Hereditary Cancer Risk Program free of charge. The minimum age is 20 years. There is no upper bound to the age provided the subject is able to give informed consent.

Exclusion Criteria:

» Female BRCA1 or BRCA2 mutation carriers under the age of 20
» Women who are BRCA1 or BRCA2 mutation carriers and pregnant
» Men who have been diagnosed with a BRCA1 or BRCA2 mutation

Location:


Breast Center - Baylor Charles A. Sammons Cancer Center
3410 Worth Street
Dallas , TX 75246

Lead Principal Investigator:

Blum, Joanne L., MD, PhD



For further information regarding this study, please contact the Office of Clinical Oncology Research Coordination at 214-818-8472 or via email at cancer.trials@baylorhealth.edu.

Last Update: May 26, 2010