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The PRISMS Study 

The PRISMS Study - Project to Improve Symptoms and Mood after Spinal Cord Injury (SCI)

 After SCI, people often have problems with poor sleep, poor energy, low mood, loss of interest in things they used to enjoy, change in appetite, feelings of worthlessness or guilt, and sometimes even thoughts of death. While nearly everyone has some of these symptoms now and then, it is not normal to have several of these symptoms at the same time for many weeks or longer. When that happens, it may be a sign that a person’s brain chemistry is out of balance.

Poor sleep, energy and mood have a harmful effect on everyday life. These symptoms can make it harder to get along with people, to take good care of oneself or to get things done at home or work. They can also make pain and other discomfort worse. Without treatment, these symptoms can last a long time, sometimes 6-12 months or more. Thoughts of death and risk of suicide are higher while people feel this way.

The PRISMS Study (Project to Improve Symptoms and Mood after SCI) examines whether an antidepressant, venlafaxine XR (also known as Effexor XR), improves sleep, energy, mood, and interest in life among people with SCI. We are studying venlafaxine XR because it prevents reabsorption of both serotonin and norepinephrine. Plus it has fewer side-effects and better pain-relieving qualities than some other antidepressant medications.

Baylor Institute for Rehabilitation is currently screening individuals who may be eligible for this study. You may qualify for this study if you have a SCI, are 18-64 years old, have some of these symptoms, are not taking venlafaxine XR and live within travelling distance to Baylor Institute for Rehabilitation in Dallas, Texas. If you would like to be considered for this study, please contact Ann Marie Warren, Ph.D. at 214.820.9315.

The PRISMS Study is funded by the National Institute on Disabilities and Rehabilitation Research; Grant Number H133A060107.

The PRISMS Study

Charles Bombardier, PhD

Jesse Fann, MD, MPH Departments of Rehabilitation Medicine and Psychiatry and Behavioral Science

Harborview Medical Center

UW Medical Center

University of Washington School of Medicine

Baylor Institute for Rehabilitation