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Drug-induced hepatitis

Definition

Drug-induced hepatitis is inflammation of the liver that may occur when you take certain medications.

See also:

Alternative Names

Toxic hepatitis

Causes

The liver helps the body break down certain drugs. However, the way it does so differs from person to person. Therefore, many different drugs can cause drug-induced hepatitis.

Painkillers and fever reducers that contain acetaminophen are a common cause of liver inflammation. These medications can damage the liver when taken in doses that are not much greater than the recommended therapeutic dose.

Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, may also cause drug-induced hepatitis.

Other drugs that can lead to liver inflammation include:

  • Amiodarone
  • Anabolic steroids
  • Birth control pills
  • Chlorpromazine
  • Erythromycin
  • Halothane
  • Methyldopa
  • Isoniazid (used to treat tuberculosis)
  • Methotrexate
  • Statins

References

Goldman L, Ausiello D. Cecil Textbook of Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007.

Review Date: 11/13/2007
Reviewed By: Christian Stone, M.D., Division of Gastroenterology, Washington University in St. Louis School of Medicine, St. Louis, MO. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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