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Sclerosing cholangitis

Alternative Names

Primary sclerosing cholangitis

Treatment

  • Antibiotics for infections in the bile ducts
  • Inserting a long, thin tube with a balloon at the end to open up narrowing (endoscopic balloon dilation of strictures)
  • Liver transplant
  • Medications (cholestyramine and ursodiol)
  • Placement of a drain or tube (endoscopic stent) for major strictures

Outlook (Prognosis)

How well patients do varies. The disease tends to get worse over time and most patients develop:

Some patients develop recurrent infections of the bile ducts. Some patients have worsening chronic liver disease with ascites and varices.

Patients with this condition have an increased risk of developing cancer of the bile ducts (cholangiocarcinoma), and should be checked on a regular basis (usually each year) with liver scans and blood tests.

Possible Complications

  • Cholangiocarcinoma
  • Cholangitis (infection of the biliary system)
  • Liver failure
  • Vitamin deficiencies

When to Contact a Medical Professional

Call your health care provider if you have jaundice and itching that do not go away.

Review Date: 2/20/2008
Reviewed By: Christian Stone, MD, Division of Gastroenterology, Washington University in St. Louis, School of Medicine, St. Louis, MO. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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