There is no specific treatment for renal papillary necrosis. Treatment depends on the underlying cause. For example, if analgesic nephropathy is suspected as the cause, your doctor will recommend that you stop using the suspected medications. This may allow healing over time.
How well a person does depends on the underlying condition. If the underlying disorder can be controlled, the condition may go away on its own. In some cases, persons with this condition develop kidney failure.
Call for an appointment with your health care provider if you have bloody urine. Also call if other symptoms of renal papillary necrosis develop, especially after taking over-the-counter pain medications.