Diabetes insipidus - nephrogenic
Alternative Names
Nephrogenic diabetes insipidus; Acquired nephrogenic diabetes insipidusSymptoms
You may have intense or uncontrollable thirst, and crave ice water. You will produce large amounts of urine, usually more than 3 - 15 liters per day.
If you do not drink enough fluids, dehydration can result. Symptoms may include:
- Dry mucus membranes
- Dry skin
- Sunken appearance to eyes
- Sunken fontanelles (soft spot) in infants
Other symptoms that can occur due to inadequate fluids include:
- Fatigue, lethargy
- Headache
- Irritability
- Low body temperature
- Muscle pains
- Rapid heart rate
- Weight loss
Exams and Tests
A physical exam may reveal:
- Low blood pressure
- Rapid pulse
- Shock
- Signs of dehydration
Testing may reveal:
- High serum osmolality
- High urine output, regardless of how many fluids you drink
- Kidneys don't concentrate urine when the person is given ADH
- Low urine osmolality
- Normal or high ADH levels
Other tests that may be done include:
References
Anatomy and Hormone Synthesis. Verbalis JG. In: Goldman L, Ausiello D, eds. Cecil Textbook of Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 243.
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