Factor XII (Hageman factor) deficiency
Definition
Factor XII deficiency is an inherited disorder with no symptoms. Factor XII is a protein involved in blood clotting. A deficiency of this factor does not cause abnormal bleeding in the affected person, but the blood takes longer than normal to clot in a test tube.
Causes
Factor XII deficiency is a rare hereditary disorder. It is usually found when clotting tests are done for routine screening. It is not associated with abnormal bleeding.
References
McPherson RA and Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. Philadelphia, Pa.: WB Saunders; 2006.
Hoffman R, Benz Jr. EJ, Shattil SJ, et al., eds. Hematology: Basic Principles and Practice. 4th ed. Philladelphia, Pa: Churchill Livingston; 2005:2089-90.
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