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Pernicious anemia

Alternative Names

Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption)

Treatment

Monthly vitamin B12 injections are prescribed to correct the vitamin B12 deficiency. This therapy corrects the anemia and may correct the neurological complications if taken soon enough.

Some doctors recommend that elderly patients with gastric atrophy take vitamin B12 supplements by mouth in addition to monthly injections.

There is also a preparation of vitamin B12 that may be given through the nose).

A well-balanced diet is essential to provide other elements for healthy blood cell development, such as folic acid, iron, and vitamin C.

Outlook (Prognosis)

The outcome is usually excellent with treatment.

Possible Complications

People with pernicious anemia may have gastric polyps and get gastric cancer and gastric carcinoid tumors twice as often than the normal population.

Persistent neurological defects may be present if treatment is delayed.

When to Contact a Medical Professional

Call your health care provider if symptoms suggestive of vitamin B12 deficiency develop.

Review Date: 8/27/2007
Reviewed By: Stephen Grund, M.D. Ph.D., Chief of Hematology/Oncology and Director of the George Bray Cancer Center at New Britain General Hospital, New Britain, CT. Review provided by VeriMed Healthcare Network.

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