Lambert-Eaton Syndrome
Definition
Lambert-Eaton syndrome is characterized by muscle weakness that improves with continued contraction of the muscle.
Alternative Names
Myasthenic syndrome; Eaton-Lambert syndromeCauses
Lambert-Eaton syndrome (myasthenic syndrome) is a disorder with symptoms very similar to those of myasthenia gravis. There is muscle weakness associated with disturbed communication between nerves and muscles.
In myasthenia gravis, the neurotransmitter acetylcholine (the chemical that transmits impulses between nerves and muscles) is blocked by antibodies to its receptor.
In Lambert-Eaton syndrome, however, the signal distortion is caused by an insufficient release of neurotransmitter by the nerve cell. As muscle contraction is continued, the amount of neurotransmitter may build up in sufficient quantities and result in increased strength.
The disorder may be associated with small-cell carcinoma of the lung and other malignancies as a paraneoplastic syndrome or with autoimmune disorders.
A.D.A.M., Inc. is accredited by
URAC, also known as the American
Accreditation HealthCare Commission. URAC's accreditation program is
the first of its kind, requiring compliance with 53 standards of quality and
accountability, verified by independent audit.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2005 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.