Congenital afibrinogenemia
Symptoms
- Bruising
- Nosebleeds
- Excessive bleeding after injury or surgery
- Gastrointestinal bleeding
- Bleeding in joints
- Miscarriage
Exams and Tests
If the health care provider suspects a bleeding disorder, laboratory tests can determine the type and extent. This disorder usually shows up in childhood, often at birth.
Tests include:
- PTT
- Prothrombin time (PT)
- Clotting time
- Fibrinogen levels
- Thrombin time
- Reptilase time
- Bleeding time
All of these tests are abnormal in afibrinogenemia.
References
Hoffman R, Benz E, Shattil S, Furie B, Cohen H. Hematology: Basic Principles and Practice. 4th ed. Philadelphia, Pa: Churchill Livingstone, 2004.
Asselta R, Duga S, Tenchini ML. The molecular basis of quantitative fibrinogen disorders. J Thromb Haemost. October 2006;4:2115-2129.
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