Avian influenza

Alternative Names

Bird flu; H5N1

Treatment

Different types of avian flu virus may cause different symptoms. Therefore, treatment may vary.

In general, treatment with the antiviral medication oseltamivir (Tamiflu) or zanamivir (Relenza) may make the disease less severe -- if you start taking the medicine within 48 hours after your symptoms start.

Oseltamivir may also be prescribed for persons who live in the same house as those diagnosed with avian flu.

The virus that causes human avian flu appears to be resistant to the antiviral medicines amantadine and rimantadine. Therefore these medications cannot be used if an H5N1 outbreak occurs.

People with severe infection may need to be placed on a breathing machine. Experts recommend that persons diagnosed with avian flu be put in isolation.

Doctors recommend that people get an influenza (flu) shot to reduce the chance of an avian flu virus mixing with a human flu virus, which would create a new virus that may easily spread.

The U.S. Food and Drug Administration has approved a vaccine to protect humans from the avian flu. Experts say the vaccine could be used if the current H5N1 virus starts spreading between people.

Outlook (Prognosis)

Prognosis depends on the severity of infection and the type of avian influenza virus that caused it. The current death rate for patients with confirmed H5N1 infection is more than 50%. The H7N7 avian flu outbreak in the Netherlands resulted in 89 confirmed human cases but only one death. An avian flu virus designates H9N2 infected 3 children in Asia; all three recovered.

Possible Complications

Pneumonia  and acute respiratory distress are seen with H5N1 infections. Infection with this virus may also lead to sepsis and organ failure.

When to Contact a Medical Professional

Call your health care provider if you develop flu-like symptoms within 10 days of handling infected birds or traveling to an area with a known avian flu outbreak.

References

US Food and Drug Administration. FDA Approves First U.S. Vaccine for Humans Against the Avian Influenza Virus H5N1. Rockville, MD: National Press Office; April 17, 2007. Release P07-68

US Centers for Disease Control and Prevention. New Laboratory Assay for Diagnostic Testing of Avian Influenza A/H5 (Asian Lineage). MMWR. February 3, 2006/55(Early Release);1.

World Health Organization. Cumulative number of confirmed human cases of avian influenza A/(H5N1) reported to WHO. Geneva, Switzerland: World Health Organization; 2006.

Beigel JH, Farrar J, Han AM, et al. Avian Influenza A (H5N1) Infection in Humans. N Engl J Med. 2005;353:1374-85.