Amylase (AM-i-lase), Lipase (LYE-pase), Protease (PROE-tee-ase)

An enzyme that helps digest foods for patients who have cystic fibrosis and digestive disorders.

Brand Name(s):

Pangestyme EC, Creon 10, Creon 20, Viokase, Viokase 16, Lipram-Pn10, Lipram-Pn16, Lipram-Pn20, Lipram 4500, Ultrase Mt20, Pangestyme CN-10, Plaretase 8000, Pangestyme CN-20, Pancrease MT 4, Ku-Zyme HP

When This Medicine Should Not Be Used:

How to Use This Medicine:

Capsule, Tablet, Coated Tablet, Delayed Release Capsule, Long Acting Capsule, Powder

• Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
• Drink a full glass of water with your medicine and plenty of fluids throughout the day.
• Take this medicine with meals and snacks as directed by your doctor.
• If the capsule opens, keep the powder away from your skin and avoid breathing in the powder.
• Swallow the capsule or tablet whole. Do not let it dissolve in your mouth.
• Do not chew or crush the coated tablet or delayed-released capsule. Swallow them whole. If the capsule is too big to swallow, open the capsule and put the contents on soft food (such as applesauce) and swallow without chewing. Do not mix the capsule with alkaline foods or liquids such as milk.
• Take the powder with meals. Avoid breathing in the powder. It can be very irritating to your lungs. Do not get the powder on your skin.

If a dose is missed:

• If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
• Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you are taking iron supplements or vitamins that contain iron.

Warnings While Using This Medicine:

• Check with your doctor before taking this medicine if you have severe pancreas disease or other medical problems.
• If you are pregnant or breast feeding, talk to your doctor before taking this medicine.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.

If you notice these less serious side effects, talk with your doctor:

• Diarrhea, constipation, nausea, or vomiting.
• Stomach upset or cramps.